May 27, 2013

New ideas for old drugs



Scientists at EPFL have uncovered the molecular basis behind some of the neurological side effects of sulfonamide antibiotics, providing doctors with possible means to minimize them in patients.

Since the discovery of Prontosil in 1932, sulfonamide antibiotics have been used to combat a wide spectrum of bacterial infections, from acne to chlamydia and pneumonia. However, their side effects can include serious neurological problems like nausea, headache, dizziness, hallucinations and even psychosis. In a recent Science publication, EPFL researchers have shown for the first time how sulfonamides can interfere with a patient’s nervous system.