January 21, 2016

Chronic stress and anxiety can damage the brain, increase the risk of major psychiatric disorders

(January 21, 2016)  A scientific review paper warns that people need to find ways to reduce chronic stress and anxiety in their lives or they may be at increased risk for developing depression and even dementia.

Led by the Rotman Research Institute at Baycrest Health Sciences, the review examined brain areas impacted by chronic anxiety, fear and stress in animal and human studies that are already published. The authors concluded that there is “extensive overlap” of the brain’s neurocircuitry in all three conditions, which may explain the link between chronic stress and the development of neuropsychiatric disorders, including depression and Alzheimer’s disease. 

Experiencing anxiety, fear and stress is considered a normal part of life when it is occasional and temporary, such as feeling anxious and stressed before an exam or a job interview. However, when those acute emotional reactions become more frequent or chronic, they can significantly interfere with daily living activities such as work, school and relationships. Chronic stress is a pathological state that is caused by prolonged activation of the normal acute physiological stress response, which can wreak havoc on immune, metabolic and cardiovascular systems, and lead to atrophy of the brain’s hippocampus (crucial for long-term memory and spatial navigation).

journal reference >>