The more that we understand the brain, the more complex it
becomes. The same can be said about the genetics and neurobiology of
psychiatric disorders. For “Mendelian” disorders, like Huntington disease,
mutation of a single gene predictably produces a single clinical disorder,
following relatively simple genetic principals. Compared to Mendelian
disorders, understanding bipolar disorder has been extremely challenging. Its
biology is not well understood and its genetics are complex.
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