Crucial steps and surprising structures revealed in the
genesis of the enzyme that divides the DNA double helix during cell replication
The proteins that drive DNA replication—the force behind
cellular growth and reproduction—are some of the most complex machines on
Earth. The multistep replication process involves hundreds of atomic-scale
moving parts that rapidly interact and transform. Mapping that dense molecular
machinery is one of the most promising and challenging frontiers in medicine
and biology.