February 3, 2015

New Nanoparticle Gene Therapy Strategy Effectively Treats Deadly Brain Cancer in Rats

(Feb.3, '15)  Despite improvements in the past few decades with surgery, chemotherapy and radiation therapy, a predictably curative treatment for glioma does not yet exist. New insights into specific gene mutations that arise in this often deadly form of brain cancer have pointed to the potential of gene therapy, but it’s very difficult to effectively deliver toxic or missing genes to cancer cells in the brain. Now, Johns Hopkins researchers report they have used nanoparticles to successfully deliver a new therapy to glioma cells in the brains of rats, prolonging their lives. A draft of the study appeared this week on the website of the journal ACS Nano.