Abstract
Use of analgesics is common and is associated with increased
risk of hearing loss in men; however, the relation has not been examined
prospectively in women. The authors prospectively examined the relation between
frequency of aspirin, ibuprofen, and acetaminophen use and risk of hearing loss
among 62,261 women aged 31–48 years at baseline (1995) in Nurses' Health Study
II. The outcome was self-reported hearing loss (n = 10,012), and the follow-up
period was 1995–2009. Cox proportional hazards regression was used to adjust
for potential confounders. During 764,247 person-years of follow-up, ibuprofen
use and acetaminophen use were independently associated with increased risk of
hearing loss, but aspirin use was not.