April 14, 2015

'Para-shooting' boron on benzene rings

(April 14, 2015)  Tuning the para position of benzene moieties is significant for creating biologically active compounds and optoelectronic materials. Yet, attaching a functional handle specifically at the para position of benzene has been challenging due to multiple reactive sites on the ring. Yutaro Saito, Yasutomo Segawa and Professor Kenichiro Itami at ITbM, Nagoya University have developed a novel iridium catalyst that enables highly para-selective borylation on benzene, leading to the rapid synthesis of drug derivatives for treating Parkinson's disease..

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