Genes
down-regulated in spaceflight are involved in the control of longevity in
Caenorhabditis elegans
How
microgravitational space environments affect aging is not well understood. We
observed that, in Caenorhabditis elegans, spaceflight suppressed the formation
of transgenically expressed polyglutamine aggregates, which normally accumulate
with increasing age. Moreover, the inactivation of each of seven genes that
were down-regulated in space extended lifespan on the ground.
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