The Yin and
Yang of stem cell quiescence and proliferation
Non-canonical
Wnt-signaling maintains a quiescent pool of blood-forming stem cells in mouse
bone marrow
Jul 19 2012
KANSAS
CITY, MO—Not all adult stem cells are created equal. Some are busy regenerating
worn out or damaged tissues, while their quieter brethren serve as a strategic
back-up crew that only steps in when demand shoots up. Now, researchers at the
Stowers Institute for Medical Research have identified an important molecular
cue that keeps quiescent mouse hematopoietic (or blood-forming) stem cells from
proliferating when their services are not needed.
read more: