Scientists
at the Mainz University Medical Center gain new insights into Taspase1 function
Exploiting
"molecular glues" to target disease relevant proteolytic enzymes
10.07.2012
Scientists
at the University Medical Center of Johannes Gutenberg University Mainz in
Germany identified a novel strategy to target the oncologically relevant
protein-cleaving enzyme Taspase1. Taspase1 levels are not only elevated in
cancer cells of patients with head and neck tumors and other solid malignancies
but the enzyme is also critical for the development of leukemias. Central to
this concept is the approach to inhibit the enzyme’s activity by 'gluing
together' individual Taspase1 molecules. The results of a study undertaken by
Professor Dr. Roland Stauber of the ENT Department at the Mainz University
Medical Center were recently published in The FASEB Journal.
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