New Study Pinpoints Structural Effects of V44M and V44A
Mutations
New research, led by Rensselaer Polytechnic Institute
researcher Chunyu Wang, has solved one mystery in the development of Familial
Alzheimer’s Disease (FAD), a genetic variant of the disease that affects a
small fraction of the Alzheimer’s population. In a paper published January 6 in
the journal Nature Communications, Wang and his team follow the trail of two
genetic mutations – V44M and V44A – known to cause FAD, and show how the
mutations lead to biochemical changes long linked to the disease.