Sutures are
a 4,000 year old technology that remain the 'gold-standard' for wound closure
by virtue of their repair strength (~100 KPa). However, sutures can act as a
nidus for infection and in many procedures are unable to effect wound repair or
interfere with functional tissue regeneration.1 Surgical glues and adhesives,
such as those based on fibrin and cyanoacrylates, have been developed as
alternatives to sutures for the repair of such wounds. However, current
commercial adhesives also have significant disadvantages, ranging from viral
and prion transfer and a lack of repair strength as with the fibrin glues, to
tissue toxicity and a lack of biocompatibility for the cyanoacrylate based
adhesives.
journal
reference: JoVE >>