April 11, 2013

Healing by the Clock




In fruit flies, intestinal stem-cell regeneration fluctuates with the time of day

Cirdacian rhythms keep time for all living things, from regulating when plants open their flowers to foiling people when they try to beat jet lag. Day-night cycles are controlled through ancient biological mechanisms, evolutionarily speaking, so in essence, a human has the same internal clock as a fly does.

These circadian clocks govern daily rhythms through genes that synchronize molecular pathways that promote or repress protein production, influencing a multitude of body functions. Even before waking, for example, our clock-driven metabolism turns on enzymes and transporters that prepare our bodies to eat and digest food.