April 11, 2013

The surprising ability of blood stem cells to respond to emergencies




A research team of Inserm, CNRS and the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch lead by Dr. Michael Sieweke of the Centre d'Immunologie de Marseille Luminy (CIML, CNRS*, INSERM**, Aix Marseille Université) and MDC, today revealed an unexpected role for hematopoietic stem cells: they do not merely ensure the continuous renewal of our blood cells; in emergencies they are capable of producing white blood cells “on demand” that help the body deal with inflammation or infection. This property could be used to protect against infections in patients undergoing bone marrow transplants, while their immune system reconstitutes itself (Nature >>)