September 15, 2015

Virus in cattle linked to human breast cancer

UC Berkeley researchers have linked bovine leukemia virus, a cancer-causing
virus prevalent in cattle, with human breast cancer.

(September 15, 2015)  A new study by UC Berkeley researchers establishes for the first time a link between infection with the bovine leukemia virus and human breast cancer.

In the study, published this month in the journal PLOS ONE and available online, researchers analyzed breast tissue from 239 women for the presence of bovine leukemia virus (BLV), comparing samples from women who had breast cancer with women who had no history of the disease. They found that 59 percent of breast cancer samples had evidence of exposure to BLV, as determined by the presence of viral DNA. By contrast, 29 percent of the tissue samples from women who never had breast cancer showed exposure to BLV.

“The association between BLV infection and breast cancer was surprising to many previous reviewers of the study, but it’s important to note that our results do not prove that the virus causes cancer,” said study lead author Gertrude Buehring, a professor of virology in the Division of Infectious Diseases and Vaccinology at UC Berkeley’s School of Public Health. “However, this is the most important first step. We still need to confirm that the infection with the virus happened before, not after, breast cancer developed, and if so, how.”

Bovine leukemia virus infects dairy and beef cattle’s blood cells and mammary tissue. The retrovirus is easily transmitted among cattle primarily through infected blood and milk, but it only causes disease in fewer than 5 percent of infected animals.

A 2007 U.S. Department of Agriculture survey of bulk milk tanks found that 100 percent of dairy operations with large herds of 500 or more cows tested positive for BLV antibodies. This may not be surprising since milk from one infected cow is mixed in with others. Even dairy operations with small herds of fewer than 100 cows tested positive for BLV 83 percent of the time.

journal reference (Open Access) >>