STAT3 deacetylation by HDAC5 is a prerequisite for central leptin action
and our ability to stay lean.
(February 29, 2016) A team of researchers at Helmholtz Zentrum München, Technische Universität München and the German Center for Diabetes Research (DZD) has identified a new mechanism that regulates the effect of the satiety hormone leptin. The study published in the journal ‘Nature Communications’ identified the enzyme HDAC5 as key factor in our control of body weight and food intake and potential target against the Yoyo dieting effect.
higher overall HDAC5 immunorreactivity (nature.com)
Why do we get fat and why is it so difficult for so many people to keep off excess weight? Researchers in the Reseach Unit Neurobiology of Diabetes led by Dr. Paul Pfluger and at the Institute for Diabetes and Obesity led by Prof. Dr. Matthias Tschöp have now identified a new component in the complex fine-tuning of body weight and food intake. They found that the enzyme histone deacetylase 5 (HDAC5) has a significant influence on the effect of the hormone leptin*. This hormone plays a crucial role in triggering satiety and thus on how the body adapts to a changing food environment.