STAT3
deacetylation by HDAC5 is a prerequisite for central leptin action
and our ability
to stay lean.
(February 29, 2016) A
team of researchers at Helmholtz Zentrum München, Technische Universität
München and the German Center for Diabetes Research (DZD) has identified a new
mechanism that regulates the effect of the satiety hormone leptin. The study
published in the journal ‘Nature Communications’ identified the enzyme HDAC5 as
key factor in our control of body weight and food intake and potential target
against the Yoyo dieting effect.
higher overall HDAC5
immunorreactivity (nature.com)
Why do we get fat and why is it so difficult for so many
people to keep off excess weight? Researchers in the Reseach Unit Neurobiology
of Diabetes led by Dr. Paul Pfluger and at the Institute for Diabetes and
Obesity led by Prof. Dr. Matthias Tschöp have now identified a new component in
the complex fine-tuning of body weight and food intake. They found that the
enzyme histone deacetylase 5 (HDAC5) has a significant influence on the effect
of the hormone leptin*. This hormone plays a crucial role in triggering satiety
and thus on how the body adapts to a changing food environment.